Cat. No. ARC1034
The KO52 cell line was established from the bone marrow of a patient with multi-lineage CD7-positive acute leukemia. Under laboratory conditions, these cells expressed specific markers to identify its lineage, such as myeloid-associated antigens (CD13, CD14, and CD33) and lymphoid markers (CD2, CD5, and CD7), as well as HLA-DR. The KO52 carries mutations in <em>p53</em> and <em>N-ras</em> gene, which are typically associated with different stages or subtypes of leukemia. When exposed to G-CSF, IL-2, PMA, or vitamin D3, KO52 cells might exhibit some characteristics of granulocytic or monocytic/macrophage-like differentiations. <br> <br>Synonym: KO-52; K052; K-052
| Sex of Donor | Male |
| Age | 46 years |
| Derived From Site | In situ; Bone marrow |
| Growth Mode | Suspension |
| Morphology | Lymphocyte-like |
| Temperature | 37°C |
| Atmosphere | 5% CO₂ |
| Sterility testing | The bacterial, yeast, and fungi are not detected in these cells by daily monitor. |
| Mycoplasma testing | Negative for mycoplasma through PCR analysis |
Intended Use: This product is intended for laboratory in vitro use only. lt is not intended for diagnostic, therapeutic, or clinical applications.
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