Immortalized Cell Line
Homo sapiens (Human)
Liver
Adherent
LX-2 cell line is human hepatic stellate cell line derived by spontaneously immortalization at low serum condition, used as a model for studying liver fibrosis. It retains the characteristic retinoid phenotype of stellate cells and expresses classic markers, including α-smooth muscle actin, vimentin, and glial fibrillary acidic protein. LX-2 cells express crucial receptors involved in fibrogenesis, such as PDGFR-β, Discoidin Domain Receptor 2, and the leptin receptor, alongside major matrix remodeling proteins like MMP-2, TIMP-2, and MT1-MMM (with reduced TIMP-1). Functionally, LX-2 cells proliferate in response to PDGF stimulation, upregulate procollagen expression upon TGF-β1 treatment, and are highly transfectable. Gene expression profiling demonstrates a striking 98.7% similarity to primary human hepatic stellate cells, including the expression of neuronal genes, confirming its close resemblance to the in vivo phenotype.
ACSS3 Knockout HAP1 Polyclonal Cells
Cat. No. ARG21605
HEXIM2 Knockout MES-OV Polyclonal Cells
Cat. No. ARG24531
ADK Knockout jurkat Polyclonal Cells
Cat. No. ARG33754
ACTR3C Knockout HEK293T Polyclonal Cells
Cat. No. ARG38035
HSPA4L Knockout HAP1 Polyclonal Cells
Cat. No. ARG27582
LONP2 Knockout AGS Polyclonal Cells
Cat. No. ARG3005
Complete description is available upon request.