In Stock Cell Lines
The ESRRA Knockout HK-2 Cell Line provides a CRISPR/Cas9-edited loss-of-function model for the nuclear receptor ERR?? in immortalized human kidney proximal tubule epithelial cells. ERR??, coactivated by PGC-1??, transcriptionally regulates genes involved in mitochondrial biogenesis and fatty acid oxidation, including PDK4 and CPT1B. This knockout line is well-suited for metabolic disease modeling, kidney disease research, and toxicology, with assays such as Seahorse metabolic flux, ATP measurement, and ROS detection. It is particularly useful for studying renal energy metabolism and mitochondrial dysfunction in conditions like diabetic nephropathy.
LGR4 Knockout SK-Hep-1 Polyclonal Cells
Cat. No. ARG15133
ACOD1 Knockout NCI-H1703 Polyclonal Cells
Cat. No. ARG36533
CASP8 Knockout 786-O Polyclonal Cells
Cat. No. ARG42521
CARD19 Knockout Hela Polyclonal Cells
Cat. No. ARG42301
FHL3 Knockout Hela Polyclonal Cells
Cat. No. ARG7691
DDR2 Knockout HEK293T Polyclonal Cells
Cat. No. ARG3781
The ESRRA Knockout HK-2 Cell Line is a CRISPR/Cas9-edited knockout cell line derived from the immortalized human kidney proximal tubule epithelial cell line HK-2.
This product provides a loss-of-function model for the ESRRA gene, enabling investigation of ERR??-dependent pathways.
The knockout line is suitable for functional genomics, metabolic profiling, and disease modeling applications.
