In Stock Cell Lines
The ESRRA Knockout HK-2 Cell Line provides a CRISPR/Cas9-edited loss-of-function model for the nuclear receptor ERR?? in immortalized human kidney proximal tubule epithelial cells. ERR??, coactivated by PGC-1??, transcriptionally regulates genes involved in mitochondrial biogenesis and fatty acid oxidation, including PDK4 and CPT1B. This knockout line is well-suited for metabolic disease modeling, kidney disease research, and toxicology, with assays such as Seahorse metabolic flux, ATP measurement, and ROS detection. It is particularly useful for studying renal energy metabolism and mitochondrial dysfunction in conditions like diabetic nephropathy.
CRIP2 Knockout HT29 Polyclonal Cells
Cat. No. ARG13968
ARHGDIA Knockout HT29 Polyclonal Cells
Cat. No. ARG33022
CAV2 Knockout huh-7 Polyclonal Cells
Cat. No. ARG42642
Atp6v0a1 Knockout HEK293T Polyclonal Cells
Cat. No. ARG38209
FNDC3B Knockout MES-OV Polyclonal Cells
Cat. No. ARG6795
LZTS1 Knockout HEK293T Polyclonal Cells
Cat. No. ARG4554
The ESRRA Knockout HK-2 Cell Line is a CRISPR/Cas9-edited knockout cell line derived from the immortalized human kidney proximal tubule epithelial cell line HK-2.
This product provides a loss-of-function model for the ESRRA gene, enabling investigation of ERR??-dependent pathways.
The knockout line is suitable for functional genomics, metabolic profiling, and disease modeling applications.
