Human Fibroblast-Like Synoviocytes from Adult Osteoarthritis Donor

Human fibroblast-like synoviocytes (FLS) from adult osteoarthritis donors are freshly isolated from synovial tissue of a donor with arthritic disease. These cells, also known as synovial fibroblasts or type B synoviocytes, are specialized stromal cells that line the synovium and are responsible for producing extracellular matrix components and synovial fluid. In osteoarthritis, FLS exhibit altered phenotypes, including increased production of inflammatory mediators and matrix-degrading enzymes. Therefore, they are widely used as in vitro models to study joint inflammation, cartilage degradation, and the molecular mechanisms underlying osteoarthritis progression.