In Stock Cell Lines
The ESRRA Knockout HK-2 Cell Line provides a CRISPR/Cas9-edited loss-of-function model for the nuclear receptor ERR?? in immortalized human kidney proximal tubule epithelial cells. ERR??, coactivated by PGC-1??, transcriptionally regulates genes involved in mitochondrial biogenesis and fatty acid oxidation, including PDK4 and CPT1B. This knockout line is well-suited for metabolic disease modeling, kidney disease research, and toxicology, with assays such as Seahorse metabolic flux, ATP measurement, and ROS detection. It is particularly useful for studying renal energy metabolism and mitochondrial dysfunction in conditions like diabetic nephropathy.
ENDOD1 Knockout A2780 Polyclonal Cells
Cat. No. ARG18792
CRIM1 Knockout A549 Polyclonal Cells
Cat. No. ARG10398
GTPBP3 Knockout Hela Polyclonal Cells
Cat. No. ARG25510
ACTN1 Knockout A549 Polyclonal Cells
Cat. No. ARG38638
C6orf47 Knockout HAP1 Polyclonal Cells
Cat. No. ARG27455
FOXO3 Knockout 786-O Polyclonal Cells
Cat. No. ARG5382
The ESRRA Knockout HK-2 Cell Line is a CRISPR/Cas9-edited knockout cell line derived from the immortalized human kidney proximal tubule epithelial cell line HK-2.
This product provides a loss-of-function model for the ESRRA gene, enabling investigation of ERR??-dependent pathways.
The knockout line is suitable for functional genomics, metabolic profiling, and disease modeling applications.
