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The ESRRA Knockout HK-2 Cell Line provides a CRISPR/Cas9-edited loss-of-function model for the nuclear receptor ERR?? in immortalized human kidney proximal tubule epithelial cells. ERR??, coactivated by PGC-1??, transcriptionally regulates genes involved in mitochondrial biogenesis and fatty acid oxidation, including PDK4 and CPT1B.
This knockout line is well-suited for metabolic disease modeling, kidney disease research, and toxicology, with assays such as Seahorse metabolic flux, ATP measurement, and ROS detection. It is particularly useful for studying renal energy metabolism and mitochondrial dysfunction in conditions like diabetic nephropathy.
999 in stock
The ESRRA Knockout HK-2 Cell Line is a CRISPR/Cas9-edited knockout cell line derived from the immortalized human kidney proximal tubule epithelial cell line HK-2.
This product provides a loss-of-function model for the ESRRA gene, enabling investigation of ERR??-dependent pathways.
The knockout line is suitable for functional genomics, metabolic profiling, and disease modeling applications.
| Product Type | In Stock Cell Lines |
|---|---|
| Size/Quantity | 1 million |
| Shipping info | Cryopreserved in vials and shipped on dry ice |
| Host Cell | HK-2 |
| Gene Name | ESRRA |
| Gene Identifier | NCBI Gene ID 2101 |
| Storage | Liquid nitrogen (LN2) |
| Temperature | 37 |
| Atmosphere | 5% CO2 |
| Sterility testing | The bacterial, yeast, and fungi are not detected in these cells by daily monitor. |
| Mycoplasma testing | Negative for mycoplasma through PCR analysis |
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