In Stock Cell Lines
The ESRRA Knockout HK-2 Cell Line provides a CRISPR/Cas9-edited loss-of-function model for the nuclear receptor ERR?? in immortalized human kidney proximal tubule epithelial cells. ERR??, coactivated by PGC-1??, transcriptionally regulates genes involved in mitochondrial biogenesis and fatty acid oxidation, including PDK4 and CPT1B. This knockout line is well-suited for metabolic disease modeling, kidney disease research, and toxicology, with assays such as Seahorse metabolic flux, ATP measurement, and ROS detection. It is particularly useful for studying renal energy metabolism and mitochondrial dysfunction in conditions like diabetic nephropathy.
ABHD17B Knockout AGS Polyclonal Cells
Cat. No. ARG26418
ITGAM Knockout CAL27 Polyclonal Cells
Cat. No. ARG35364
CAAP1 Knockout MES-OV Polyclonal Cells
Cat. No. ARG41691
EIF2AK4 Knockout Hela Polyclonal Cells
Cat. No. ARG40986
PCYT2 Knockout 786-O Polyclonal Cells
Cat. No. ARG4752
MUC1 Knockout Raji Polyclonal Cells
Cat. No. ARG0990
The ESRRA Knockout HK-2 Cell Line is a CRISPR/Cas9-edited knockout cell line derived from the immortalized human kidney proximal tubule epithelial cell line HK-2.
This product provides a loss-of-function model for the ESRRA gene, enabling investigation of ERR??-dependent pathways.
The knockout line is suitable for functional genomics, metabolic profiling, and disease modeling applications.
