In Stock Cell Lines
The ESRRA Knockout HK-2 Cell Line provides a CRISPR/Cas9-edited loss-of-function model for the nuclear receptor ERR?? in immortalized human kidney proximal tubule epithelial cells. ERR??, coactivated by PGC-1??, transcriptionally regulates genes involved in mitochondrial biogenesis and fatty acid oxidation, including PDK4 and CPT1B. This knockout line is well-suited for metabolic disease modeling, kidney disease research, and toxicology, with assays such as Seahorse metabolic flux, ATP measurement, and ROS detection. It is particularly useful for studying renal energy metabolism and mitochondrial dysfunction in conditions like diabetic nephropathy.
CALCOCO2 Knockout huh-7 Polyclonal Cells
Cat. No. ARG41815
PEX14 Knockout NCI-H1975 Polyclonal Cells
Cat. No. ARG16783
NSDHL Knockout A549 Polyclonal Cells
Cat. No. ARG10431
GPATCH2L Knockout jurkat Polyclonal Cells
Cat. No. ARG34180
HSF1 Knockout HGC-27 Polyclonal Cells
Cat. No. ARG36133
GMPR2 Knockout HEK293T Polyclonal Cells
Cat. No. ARG4351
The ESRRA Knockout HK-2 Cell Line is a CRISPR/Cas9-edited knockout cell line derived from the immortalized human kidney proximal tubule epithelial cell line HK-2.
This product provides a loss-of-function model for the ESRRA gene, enabling investigation of ERR??-dependent pathways.
The knockout line is suitable for functional genomics, metabolic profiling, and disease modeling applications.
