Immortalized Cell Line
Homo sapiens (Human)
Liver
Adherent
LX-2 cell line is human hepatic stellate cell line derived by spontaneously immortalization at low serum condition, used as a model for studying liver fibrosis. It retains the characteristic retinoid phenotype of stellate cells and expresses classic markers, including α-smooth muscle actin, vimentin, and glial fibrillary acidic protein. LX-2 cells express crucial receptors involved in fibrogenesis, such as PDGFR-β, Discoidin Domain Receptor 2, and the leptin receptor, alongside major matrix remodeling proteins like MMP-2, TIMP-2, and MT1-MMM (with reduced TIMP-1). Functionally, LX-2 cells proliferate in response to PDGF stimulation, upregulate procollagen expression upon TGF-β1 treatment, and are highly transfectable. Gene expression profiling demonstrates a striking 98.7% similarity to primary human hepatic stellate cells, including the expression of neuronal genes, confirming its close resemblance to the in vivo phenotype.
A2M Knockout AGS Polyclonal Cells
Cat. No. ARG26392
KIAA1671 Knockout Hela Polyclonal Cells
Cat. No. ARG26361
ATRAID Knockout huh-7 Polyclonal Cells
Cat. No. ARG28045
BABAM1 Knockout NCI-H1299 Polyclonal Cells
Cat. No. ARG30498
ASIC1 Knockout A549 Polyclonal Cells
Cat. No. ARG34526
SUP-T1
Cat. No. ARC0906
Complete description is available upon request.