MDA-MB-453

MDA-MB-453 is a human breast cancer cell line, derived from a malignant pleural effusion of a 48-year-old female with metastatic carcinoma of the breast. The cell line is triple-negative (ER^-, PR^-, HER^-). It expresses a high level of androgen receptor and is responsive to androgen stimulation, which leads to increased proliferation of MDA-MB-453 that can be inhibited by anti-androgens. The MDA-MB-453 is non-tumorigenic in immunosuppressed mice, but tumorigenic when growing in semisolid medium. <br> <br>Synonym: MDA-MB 453; MDA MB 453; MDA-MB453; MDAMB453; MDA-453; MDA453 <br> <br> <span style="font-size:14px"> <br>[1] K. Ding et al., “Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer,” Mar. 20, 2024, Cancer Biology. doi: 10.1101/2024.03.18.585626. <br>[2] S. W. McLeskey, I. Y. F. Ding, M. E. Lippman, and F. G. Kern, “MDA-MB-134 Breast Carcinoma Cells Overexpress Fibroblast Growth Factor (FGF) Receptors and Are Growth-inhibited by FGF Ligands”. <br>[3] B. L. Witt and T. O. Tollefsbol, “Molecular, Cellular, and Technical Aspects of Breast Cancer Cell Lines as a Foundational Tool in Cancer Research,” Life, vol. 13, no. 12, p. 2311, Dec. 2023, doi: 10.3390/life13122311. <br>[4] S. E. Smith et al., “Molecular characterization of breast cancer cell lines through multiple omic approaches,” Breast Cancer Res., vol. 19, no. 1, p. 65, Dec. 2017, doi: 10.1186/s13058-017-0855-0. </span>