MDA-MB-453

Short Description 🔒

MDA-MB-453 is a human breast cancer cell line, derived from a malignant pleural effusion of a 48-year-old female with metastatic carcinoma of the breast. The cell line is triple-negative (ER^-, PR^-, HER^-). It expresses a high level of androgen receptor and is responsive to androgen stimulation, which leads to increased proliferation of MDA-MB-453 that can be inhibited by anti-androgens. The MDA-MB-453 is non-tumorigenic in immunosuppressed mice, but tumorigenic when growing in semisolid medium.
 
Synonym: MDA-MB 453; MDA MB 453; MDA-MB453; MDAMB453; MDA-453; MDA453
 

[1] K. Ding et al., “Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer,” Mar. 20, 2024, Cancer Biology. doi: 10.1101/2024.03.18.585626.
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