Cancer (Tumor) Cell Lines

Cancer (Tumor) Cell Lines are immortal cells derived from benign and malignant tumors, retaining many genetic and phenotypic features of the original tumor/cancer. This category covers cancer cell lines, tumor cell lines, and malignant cell lines. These are indispensable for oncology research, drug discovery, mechanistic studies, and xenograft models. Our portfolio includes tumor cell lines from diverse origins: carcinomas (epithelial origin), sarcomas (mesenchymal), leukemias, lymphomas, and neuroectodermal tumors. A cancer cell line can be carcinoma cell lines (e.g., breast, lung, colon), leukemia cell lines (e.g., HL-60, K562), lymphoma cell lines (e.g., Raji, Jurkat), and others. Specific types include neuroblastoma cell line (e.g., SH-SY5Y, SK-N-BE, IMR-32), which are used for pediatric cancer research and neuronal differentiation studies. Glioblastoma cell lines (e.g., U87, U251, T98G, LN229, A172) model aggressive brain tumors; they are used for temozolomide resistance, invasion assays, and xenograft models. Melanoma cell lines (e.g., A375, SK-MEL-28, M14, WM115) are used for studying BRAF mutations, immunotherapy resistance, and metastasis. Osteosarcoma cell lines (e.g., U2OS, Saos-2, MG63, HOS, 143B) are bone cancer models used for studying p53 pathways, chemotherapy sensitivity, and bone metastasis. Cervical cancer cells (e.g., HeLa, SiHa, CaSki, C33A) are used for HPV research, cell cycle studies, and drug screening; HeLa is the most famous human cell line. Breast cancer cell lines (e.g., MCF7, MDA-MB-231, T47D, BT474, SK-BR-3, ZR-75-1) cover ER-positive, HER2-positive, and triple-negative subtypes; they are used for hormone therapy, targeted therapy, and metastasis research. Lung cancer cell lines (e.g., A549, NCI-H460, NCI-H1975, NCI-H1299, HCC827) include adenocarcinoma, large cell, and small cell types; they are used for EGFR inhibitor testing and KRAS studies. Colon cancer cell lines (e.g., HCT116, HT29, SW480, Caco-2, DLD-1, LoVo) are used for Wnt signaling, mismatch repair, and drug screening (5-FU, oxaliplatin). Prostate cancer cell lines (e.g., LNCaP, PC3, DU145, 22Rv1, VCaP) cover androgen-sensitive and castration-resistant types; they are used for androgen receptor studies and bone metastasis models. Pancreatic cancer cell lines (e.g., PANC-1, MIA PaCa-2, BxPC-3, AsPC-1, Capan-2) are used for KRAS studies, desmoplasia, and gemcitabine resistance. Liver cancer cell lines (e.g., HepG2, Huh7, PLC/PRF/5, Hep3B, SNU-449) are used for drug metabolism, hepatitis studies, and sorafenib testing. Ovarian cancer cell lines (e.g., OVCAR3, SK-OV-3, A2780, CAOV3, ES-2) are used for platinum resistance and PARP inhibitor studies. Bladder cancer cells (e.g., T24, UM-UC-3, RT4, 5637, J82) are used for chemotherapy testing and urothelial carcinoma models. Kidney cancer cells (e.g., ACHN, 786-O, Caki-1, Caki-2, 769-P) are used for clear cell renal cell carcinoma research, including VHL and HIF pathways. Gastric cancer cells (e.g., MKN45, AGS, NCI-N87, KATO III, SNU-1) are used for HER2 testing, chemotherapy, and Helicobacter pylori studies.

Researchers use tumor/cancer cell lines for drug screening, mechanistic studies, and xenograft models. Glioblastoma cell lines are used for brain cancer research, including studies on the blood-brain barrier and temozolomide resistance. Breast cancer cell lines like MCF7 and MDA-MB-231 model hormone-dependent and triple-negative cancers. Our tumor cell lines are authenticated by STR profiling, tested for mycoplasma, and provided with doubling times and growth media. Whether you need a neuroblastoma cell line for pediatric cancer, osteosarcoma cell lines for bone sarcoma, or gastric cancer cells for digestive oncology, our Cancer (Tumor) Cell Lines category supports your oncology research with well-characterized, reproducible models.