Integumentary System

The integumentary system is the outermost layer of the body, mainly consisting of skin, nails, and hair, with the supporting tissues: such as glands, nerves, and blood vessels. As the outer layer, the integumentary system, especially skin, is typically referred to as the first barrier of defense against bacteria, viruses, and other microbes from external environment. It protects the body from harmful UV radiation, regulate temperature, assistant to detect sensations.

Investigations on the cells of integumentary system involve the understanding of skin diseases, mechanisms of wound healing and regeneration, assessment of skin toxicity for pharmaceuticals and cosmetics, mechanisms of skin aging and pigmentation, etc. Key cell types include human keratinocytes, human epidermal keratinocytes (skin keratinocytes), oral keratinocytes, mouse keratinocytes, and human sebocytes. These cells are essential in skin health, renewal, and response to environmental stressors.

Additionally, human follicle dermal papilla cells are integral to hair follicle biology, including hair growth cycles and hair regeneration. Research into these cells aids in understanding alopecia, hair regeneration, and skin-related cosmetic treatments.